I’ll go first. Mine is the instant knockout drug. Like Dexter’s intramuscular injection that causes someone to immediately lose consciousness. Or in the movie Split where there’s the aerosol spray in your face that makes you instantly unconscious. Or pretty much any time someone uses chloroform.
Filmed in a real setting always looks less distracting than a green screen.
I agree, I’m just saying that I doubt many will go through the trouble unless it’s really necessary.