I recently installed it on my gaming PC with an Nvidia GPU and AMD CPU. It was my first time with Linux and I was partitioning a drive to dual boot windows in case I screwed the whole thing up and needed a fall back. I hit a few speed bumps mostly due to lack of experience and the dual booting (stupid secure boot!).
Beyond that my only issue so far has been an inability to get my VPN app running but since this is just a gaming PC that I don’t use for anything else I’ve just gone without the VPN. The Nvidia GPU has not really caused any problems for me so far to be honest.
I’ve only tried two games so far, Cyberpunk so I could benchmark graphical performance against Windows, and Return to Moria because I wanted to test a cheap game that specifically says it’s not Steamdeck compatible. Both tests have been successful as far as I’m concerned. I will mention that I’m pretty exclusively a solo gamer and I’ve heard that people have had issues with trying to play Return to Moria with friends.
I find the plastic floss picks work really well because they are flatter than regular tooth picks. It has to be the type where the back part is a pick as that’s the part that I use.