The Matapedia Valley from Quebec into Northern New Brunswick is a gorgeous drive. I love driving in NB but take the old highway along the coast. The new highways go through replanted forest and all you see are pine trees. I haven’t driven a lot in Nova Scotia or PEI. Newfoundland is great though. Take the ferry to Port aux Basques and drive around the island to St. John’s. You can depart from the Argentia ferry.

Edited because autocorrect.